INVESTIGADORES
GEFFNER Jorge Raul
artículos
Título:
The effect of fludarabine on interferon-gamma production by lymphoid cells from healthy donors and patients with B-cell chronic lymphocytic leukemia.
Autor/es:
GAMBERALE R, FERNÁNDEZ-CALOTTI P, SÁNCHEZ-AVALOS J, ALBERTO MF, GEFFNER J, GIORDANO M.
Revista:
HAEMATOLOGICA
Editorial:
HighWire Press
Referencias:
Lugar: Pavia, Italia; Año: 2006 vol. 91 p. 574 - 576
ISSN:
0390-6078
Resumen:
Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently ill-defined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-gamma, a key cytokine in the pathogenesis of AHA.
