Estimation of genetic variability level in inbred CF1 mouse lines selected for body weight

RENNY M., JULIO, N.B., BERNARDI S.F., GARDENAL C.N. Y OYARZÁBAL M.I.

JOURNAL OF GENETICS

INDIAN ACAD SCIENCES

Lugar: Bangalore ; Año: 2013

0022-1333

To estimate the genetic variability levels maintained by inbred lines selected for body weight and to compare them with a non-selected population from which the lines derived, we calculated percentages of polymorphic loci and M (Marker Diversity) index from data on 43 putative loci of ISSR (Inter Simple Sequence Repeats). After 60 generations of selection and inbreeding by limitation of number, the percentages of polymorphic loci ranged between 5% and 27.5% and were closely related to the effective size of each line. The overall genetic differentiation among them was enough to obtain highly divergent mouse lines in phenotype by artificial selection.