INQUISUR 21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
informe técnico
Título:
University of Chicago, Department of Computer Science, Technical Report
Autor/es:
RIDGWAY SCOTT; ARIEL FERNANDEZ
Fecha inicio/fin:
2018-10-01/2018-10-27
Naturaleza de la
Producción Tecnológica:
Biológica
Campo de Aplicación:
Enf.No Endemicas-Degenerativas
Descripción:
TR-2018-08Inoperative Checkpoint Immunotherapies Rescued Via Companion Targeted TherapiesAriel Fernandez; L. Ridgway Scott. 28 October, 2018.Communicated by L. Ridgway Scott.AbstractImmune checkpoint blockers revolutionized cancer therapy. Yet, they met only modest success when treating tumors where regulatory T cells recruited at the tumor periphery overwhelmingly suppress the adaptive immune response. To achieve lasting cure, we propose immuno-tuning combinations with purposely engineered targeted agents that block indirect tumor-induced immunosuppression without adversely impacting the adaptive response.Original DocumentThe original document is available in PDF (uploaded 28 October, 2018 by L. Ridgway Scott).
