Alginate-hydroxyapatite composites for guided bone regeneration: rheology and tensile strength

D'ELÍA NOELIA L.; ERCOLI, DANIEL; MESTRES, GEMMA; SARTUQUI JAVIER; MESSINA, PAULA V.; RIAL SILVA, RAMON; RUSO, JUAN M.

Buenos Aires

Simposio; XIII Simposio Argentino de Polímeros - SAP; 2019

UTN Facultad Regional Buenos Aires

Guided bone regeneration (GBR) is widely employed and consists on covering an osseous defect with a barrier membrane. This aims to, on one hand, support the ingrowth of osteogenic cells avoiding cell competition and, on the other hand, to achieve mechanical stabilization and therefore preventing micromovements of the bone graft (Dimitriou, Mataliotakis, Calori, & Giannoudis, 2012). Recently, our research group developed a bioactive alginate ? hydroxyapatite nanoparticles (ALG/nHA) composite, where nHA were used as crosslinking agent of the polymer (Benedini, Placente, Pieroni, & Messina, 2017). The aim of this research proposal is two-fold: first, to study the rheological properties of the hydrogels while forming and, second to evaluate the tensile resistance of the dry membranes using different nHA concentrations. The final objective is to develop a biodegradable and bioactive membrane with enhanced mechanical properties to stimulate bone formation in maxillofacial applications