Biomembranes applied to guided bone regeneration

D'ELÍA NOELIA LAURA

Santiago de Compostela

Encuentro; Applications of bioceramic materials in pharmacy and medicine meeting.; 2018

Universidad de Santiago de Compostela

Guided bone regeneration is widely employed, especially in the oral-maxillofacial region. The first approach consisted on the application of a barrier membrane to cover an osseous defect with the main objectives of: (a) covering a bone defect supporting the ingrowth of osteogenic cells without competition from other cells, and (b) achieving mechanical stabilization and therefore preventing micromovement of the bone graft. In recent years, various membranes applied for guided bone regeneration have been developed. Among them, biodegradable membranes have the advantage to avoid a second surgical procedure to extract them and bioactive membranes ensure a tight bonding of the biomaterial within the host tissue. The aim of this research was to develop a biodegradable and bioactive membrane to enhance bone formation in maxillofacial applications. The composition of the membrane is ALG/nHA with VEGF encapsulated, where nHA present in a gradient form (with most of nHA on one side, where bone formation will be promoted). Therefore, rather than merely acting as a passive barrier, the membrane will guide bone regeneration due to its osteoconductive and osteoinductive properties on the bone defect side, and it promotes wound healing on the other side. In summary, the gradient membrane promotes angiogenesis along the entire material and osteogenesis in the side of the bone defect.