The antitumoral effects of HO-1 in colorectal cancer are dependent on the presence of a wild type p53.

ALONSO, EN; FERMENTO, ME; ABBA, M; FACCHINETTI, MM; FERRONATO, MJ; ANDRÉS, NC; CURINO, AC; GANDINI, NA; MARQUESTAUT, M; MASSILLO, C

Mar del Plata

Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2016

SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC)

Previously, we reported that heme oxygenase-1 (HO-1) is associated with increased overall survival time of patients with invasive colorectal cancer (CRC) and that HO-1 activation decreases the viability of human CRC cell lines that carry a wild-type p53 although it has no effect on cells with absent/mutated p53. The hypothesis of this work is that p53 might be involved in the antitumoral effect of HO-1 in CRC. By using a xenograft of p53 wild type-containing HCT116, we first demonstrated that genetic overexpression of HO-1 delayed tumor growth (p