Design, Synthesis and Characterization of a novel azoniosome

SEQUIEIRA ALEJANDRA; MALIC IVANA; BENEDINI LUCIANO; DODERO VERONICA

Carlos Paz, Cordoba

Congreso; XLII Reunión Anual de la Sociedad Biofísica Argentina; 2013

Sociedad Argentina de Biofisica

Niosomes are promising new systems for Drug Delivery. They possess a vesicular lamellar structure similar to liposomes; however they are constituted by mixtures of water insoluble ionic surfactants and cholesterol [1]. Various groups have attempted to use this event to design vesicular systems based on azoamphiphiles using either ionic or non-ionic head. However, the selection of the polar group head and its relationship with the tail of the amphiphile was not adequate to achieve the formation of vesicular aggregates and/or the photomodulation in water [2, 3]. Through the design and chemical synthesis, we obtained a new non-ionic azoamphiphile whose relative head / linker/ tail is optimal for the formation of photoswitchable vesicles. This system has potential use as a phototriggered drug delivery system or azoniosome.