BENZOPHENONE-3 LOADED MICROEMULSION FOR A POTENTIAL USE AS SUNSCREEN. THERMAL STABILITY AND PERMEATION ANALYTICAL STUDIES

DAMIAN URIARTE; MARCOS GRUNHUT; VERÓNICA VOLPE; MARIANO GARRIDO; CLAUDIA DOMINI

Córdoba

Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas (RICiFa 2020+1); 2021

Universidad Nacional de Córdoba/Universidad Nacional de Rosario

Benzophenone-3 (BP-3) is a UVA-B liposoluble absorber that may undergo thermodegradation with decreased efficiency in sunscreens. Microemulsions can protect labile compounds against thermal degradation. This research proposes a BP-3 loaded microemulsion (ME-BP3) based on the use of biocompatible materials and the evaluation of its thermal stability and permeation dynamics.BP-3 was loaded (2.0% w/w) into a microemulsion consisting of tween 80-ethanol (42.0% w/w), isopropyl miristate (2.5% w/w) and water (55.5% w/w). The particle size was 11.90 nm and the polidispersity index was 0.224.The thermodegradation study was performed at 60°C and monitored by synchronous fluorescence spectroscopy (350-690 nm) for 80 min. The fluorescent signal for ME-BP3 was constant over time. However, the signal for BP-3 in non-organized medium was decreasing over time (k=1.26 h-1).The permeation of BP-3 was monitored by UV-Vis (290 nm) using an on-line system. The permeation constant (kp) was 4.07x10-6 cm min-1, a lower value compared to a BP-3 in non-organized medium (1.45x10-6 cm min-1). The proposed carrier for BP-3 was successfully obtained and it offered a higher thermal stability and a lower permeation rate in comparison to BP-3 in a non-organized medium. This results are promisory for a potential use of ME-BP3 as sunscreen.