INQUISUR   21779
INSTITUTO DE QUIMICA DEL SUR
Unidad Ejecutora - UE
artículos
Título:
A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems
Autor/es:
VERÓNICA LASSALLE; MARCELO AVENA; MARÍA LUJÁN FERREIRA
Revista:
Current Trends in Polymer Science
Editorial:
Research Trends Ltd.
Referencias:
Lugar: Trivandrum; Año: 2009 vol. 13 p. 37 - 67
ISSN:
0972-446X
Resumen:
ABSTRACT
Iron oxide-based magnetic nanoparticles (IONP)
that display high saturation and high magnetic
susceptibility are of great interest for
biotechnological and biomedical applications.
Magnetite displays strong ferrimagnetic behaviour
and is less sensitive to oxidation than other
magnetic transition metaloxides. It is then not
surprising that IONP include magnetite in their
formulation. The role of IONP technology in the
cited areas requires specific characteristics
with regard to the particle size and surface
functionality. Therefore the incorporation of
polymeric moieties appears as a valuable
tool to achieve the desired properties. On this
context surface-modified IONP and magnetic
nanocomposites (MNC) can be obtained depending
on the role of the polymeric network in the
formulation process. The methods to prepare
each kind of magnetic-polymeric composite are
reviewed in this work. First, the different kinds
of IONP are carefully analyzed and second, the
techniques available to incorporate polymer and
other modifiers, are addressed. An investigation
of the relationship between the nature of the
modifier and the tailored application of the
generated particles is also included with the focus
mainly in the effect of some experimental
variables on the nanoparticle size. Finally, two
specific applications of magnetic nanocomposites
in novel and relevant fields will be discussed. The
role of magnetic nanoparticles as drug delivery
systems (DDS) is of high significance and
consequently, the available information is
rich, but it is mostly dedicated to the sustained
release of anticancer drugs. Here we will show
other drugs, able to be delivered from magnetic
DDS. MNC have recently emerged as effective
supports for lipase immobilization. The reported
data concerning to this topic is still quite limited
and therefore novel published advances are
reviewed here.