Mechanical performance of gelatin fiber mesh scaffolds reinforced with nano-hydroxyapatite under bone damage mechanisms

SARTUQUI, JAVIER; DE ALCAZAR, DANIEL SÁNCHEZ; SARTUQUI, JAVIER; DE ALCAZAR, DANIEL SÁNCHEZ; D'ELÍA, NOELIA L.; CORTAJARENA, AITZIBER L.; D'ELÍA, NOELIA L.; CORTAJARENA, AITZIBER L.; ERCOLI, DANIEL; MESSINA, PAULA V.; ERCOLI, DANIEL; MESSINA, PAULA V.

Materials Today Communications

Elsevier Ltd

Lugar: Amsterdam; Año: 2019 vol. 19 p. 140 - 147

Nota:Aparezco en la posición 2 en la lista de autores de la publicación pero soy co-primer autor (ver artículo anexado).Engineered tissues scaffolds should be design to mimic, at least partially, the extracellular matrix (ECM) in native tissues. Our scaffold´s design satisfies, important challenges among the implant architecture requirements: (i) a fiber mesh entanglement mimicking physical attributes of natural ECM; (ii) a nanostructure surface roughness and chemical cues to increase the interaction with host tissue; (iii) a hydrolytic and enzymatic biodegradability; (iv) an open interconnected macroporosity to promote highly permeability and (v) a tensile stability under mechanical damage mechanisms. These properties are very important for cell seeding, adhesion, vascularization, new ECM formation and the subsequent tissue regeneration.