Electroactive Mg2+- Hydroxyapatite Nanostructured Networks against Drug - Resistance Bone Infection Strains

MÓNICA BALDINI; PAULA V. MESSINA; JUAN M. SIEBEN; ÁNGELA FAMIGLIETTI; NANCY C.ANDRÉS; CARLOS HERNÁN RODRÍGUEZ

ACS APPLIED MATERIALS & INTERFACES

AMER CHEMICAL SOC

Lugar: Washington; Año: 2018 p. 19534 - 19544

1944-8244

Surface colonization competition between bacteria and host cells, is ones of the critical factors involved during tissue / implant integration. Current biomaterials are evaluated both for their ability to withstand favourable responses of host tissue cells and to resist bacterial contamination. In this work, the antibacterial ability of biocompatible Mg2+ - substituted nanostructured hydroxyapatite (HA) was investigated. The densities of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli strains was significantly decreased after culture in the presence of Mg-substituted HA materials in a direct correlation with Mg2+- Ca2+ switch in the HA lattice. It was notice that this diminution was accompanied with a minimal alteration of bacterial environments, therefore the Mg2+ - HA antibacterial effect was associated with the material surface topography and it electroactive behaviour. 2.23 Wt% Mg2+- HA samples exhibited the best antibacterial performance, it decreased two-folds the initial population of E. coli, P. aeruginosa and S. aureus at the intermediate concentration (50 mg / mL of broth). Our results reinforce the aptitude of Mg-HA nanostructured materials to be used in antibacterial coatings for implantable devices and/or medicinal materials to prevent bone infection and to promote wound healing.