INVESTIGADORES
FURLAN Ricardo Luis Eugenio
artículos
Título:
Chemically engineered extracts: bioactivity alteration through sulphonylation
Autor/es:
SALAZAR, MO; RAMALLO, IA; MICHELONI, O; GONZALEZ SIERRA, M; FURLAN, RLE
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2009 vol. 19 p. 5067 - 5070
ISSN:
0960-894X
Resumen:
The access to libraries of molecules with interesting biomolecular properties is a limiting step in the drug discovery process. We report here that the chemical composition of crude herbal extracts can be altered in a significant way using sulphonylation, and how such chemical alteration can affect in a positive way some biomolecular properties of the mixtures. The result illustrates how biological activity can be generated by designed chemical diversification of a natural product mixture, and represents a proof of principle of an alternative strategy for producing natural product-like libraries from natural products libraries
