A New Cyclic Pseudo-Peptide Receptor for Li+ from a Dynamic Combinatorial Library

FURLAN, RLE; NG, YF; OTTO, S; SANDERS, JKM

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

American Chemical Society

Lugar: Washington; Año: 2001 vol. 123 p. 8876 - 8877

0002-7863

Dynamic combinatorial chemistry (DCC) has emerged as a new strategy for the discovery of novel host-guest systems. In theory the dynamic combinatorial approach integrates preparation, identification, and high-yield isolation of receptors in one process. To date very few examples exist where this is actually demonstrated in practice. Herein we report one such example where Li+ ions select an unpredictable cyclic pseudopeptide receptor from a small dynamic combinatorial library (DCL) of at least 10 different macrocycles. The cation converts this complex mixture into one that contains 98% of the Li+ receptor. This is the first time that a new receptor has been identified and isolated from a DCL