Identification and Isolation of a Receptor for N-methyl Alkylammonium Salts: Molecular Amplification in a Pseudo-peptide Dynamic Combinatorial Library.

COUSINS, GRL; FURLAN, RLE; NG, YF; REDMAN, JA; SANDERS, JKM

ANGEWANDTE CHEMIE

Wiley

Lugar: Berlin; Año: 2001 vol. 40 p. 423 - 428

0570-0833

We report molecular amplification from a dynamic combinatorial library (DCL) of pseudo-peptides of a macrocyclic receptor that binds selectively to acetylcholine and N-methyl quinuclidinium salts. The shifts in product distribution we report are to our knowledge the largest yet observed for covalent dynamic combinatorial systems, and serve as proof of the concept that dynamic combinatorial chemistry (DCC) may be used to identify and isolate new molecules from large pools of candidates through noncovalent template effects.