Preparation of aliskiren copper(II) complex and solution studies by EPR and UV-vis spectroscopies.

ISLAS M. S.; GRELA A.; FERRER E.G; P.A.M. WILLIAMS

Santa Fé

Workshop; III Workshop on Magnetic Resonance NMR and EPR at the Forefront of Research; 2016

UNL

Aliskiren (Alk) represents the first in a novel class of renin inhibitors with thepotential for treatment of hypertension and related cardiovascular diseases1. With the aim of improving the pharmacological effects of different compounds by inducing favorable conformational changes or by improving their bioavailability, our group has been working with metal complexation. Herein, we have prepared a solid complex at pH 12 and studied the interaction of the ligand and the metal at different pH values using Electron Paramagnetic Resonance (EPR) and UV-visible spectroscopies.