Azilsartan and its Zn(II) complex. Synthesis, anticancer mechanisms of action and interaction with bovine serum albumin.

V.R. MARTÍNEZ; M.V. AGUIRRE; J.S. TODARO; O.E.PIRO; GUSTAVO ETCHEVERRÍA; E.G. FERRER; P.A.M. WILLIAMS

Buenos Aires

Congreso; XLIX Reunión Anual de la Sociedad Argentina de Farmacología Experimental; 2017

SAFE

Azilsartan is the eighth approved member of angiotensin II receptorblockers for hypertension treatment. Considering that some drugshave additional beneficial effects on health when administered, westudied its effects and mechanisms of action on a human lung cancercell line A549. We have also modified the structure of the drugby complexation with Zn(II) cation and determined the anticancereffect.