Novel anti-depressant activity in animal model of Zn(II)-S-methyl-cysteine complex and other pharmacological activities.

E.G. FERRER; G.E. ESCUDERO; N. MARTINI; K.JORI; N.JORI; N.R. MARESCA; C.H. LAINO; P. A. M. WILLIAMS

Angra dos Reis

Simposio; 5º SIMPOSIO LATINOAMERICANO DE QUÍMICA DE COORDINACIÓN Y ORGANOMETÁLICA, 5th LATIN AMERICAN SYMPOSIUM ON COORDINATION AND ORGANOMETALLIC CHEMISTRY.; 2015

Federal University of Minas Gerais - Brazil

The antidepressant-like effect of simple Zn(II) salts has been proved in several animal models of depression1. In this study, a coordination metal complex of Zn(II) having a sulfur containing ligand is tested as antidepressant for the first time. Treatment of Zn(S-Met)2 (S-Met= S-methyl-L-cysteine) in the rat forced swimming test model of depression shows a decrease in the immobility and an increase in the swimming behavior being this action more effective and remarkable than ZnCl2 (synergic effect as a result of the coordination).