INVESTIGADORES
FERNANDEZ CIRELLI Alicia
artículos
Título:
Chemical Modification of Glycosaminoglycans. Sulphation of Heparan Sulphates Derivatives Obtained by Pertiodate Oxidation/ Borohydride Reduction
Autor/es:
J. KOVENSKY; A. FERNÁNDEZ CIRELLI
Revista:
CARBOHYDRATE POLYMERS
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 1996 vol. 31 p. 211 - 214
ISSN:
0144-8617
Resumen:
Two heparan sulphates, of different N- and O-sulphate content and iduronic/ glucuronic acid ratio (HS I and HS II), were submitted to partial periodate oxidation, borohydride reduction and subsequent O-sulphation. The sulphated derivatives showed increased anticoagulant activities by APTT assay and were significantly degraded by heparinase.
