Effects of the E. coli exotoxin alpha-hemolysin on human chorioamniotic membranes

PUCCI MOLINERIS, M; ACCIALINI, P; PELINSKI, P; BARBERO, H; FARINA, M; HERLAX, V

Congreso; 2019 IFPA - VIII SLIMP; 2019

Objectives: premature rupture of membranes is associated to urinary tract infections in pregnant women. Therefore, the main aim of this study is to evaluate the effect of alpha-hemolysin (HlyA) in remodeling of chorioamniotic extracellular matrix in vitro.Conclusion: E. coli HlyA toxin by itself is capable of triggering events relating to remodeling of chorioamniotic extracellular matrix in vitro. This observation suggest that the blockeage of HlyA may contribute to diminish damage on fetal membrane.