Comparative assessment of microspheres of cholesterol-PMMA obtained by supercritical fluid and emulsification techniques, used in controlled drug delivery

M.A. FANOVICH, C. ELVIRA, M. FERNÁNDEZ, J. SAN ROMÁN, J. FRAILE, C. DOMINGO

Chemical Engineering Transactions

Año: 2004; p. 551 - 556

The main objective of this study is to advance the SCF-impregnation process to provide information for the infusion of additives into nonporous polymeric substrates. PMMA and PMMA/PCL polymers are used as matrixes. Cholesterol are used as adsorbate. A conventional method for preparing cholesterol-containing PMMA particles is also described. Finally, a comparison of drug release from particles obtained using both methods, the supercritical and the conventional, is presented.