INCREASED ACTIVATION MARKERS ON CIRCULATING CD4 LYMPHOCYTES OF PATIENTS WITH MOOD DISORDERS

TIFNER, VERA; ARENA, ÁNGELES R.; GRENDAS, LEANDRO N.; PENNA, MELINA B.; HUNTER, FERNANDO; OLAVIAGA, ALEJANDRO; PROKOPEZ, CINTIA; ARMESTO, ARNALDO R.; CARRERA SILVA, E. ANTONIO; DARAY, FEDERICO M.; ERRASTI, ANDREA E.

Buenos Aires

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2021; 2021

SAIC SAI AAFE Nanomed

Mood Disorders (MD) are highly prevalent psychiatric conditions occurring early in life and follow a relapsing and remitting course. During the last years, emerging literature associated MD with increased inflammatory status and unbalanced immune response. This was particularly evident in patients with no response to the conventional treatment, giving rise to the inflammatory theory of depression. This study aimed to determine the activation status of circulating CD4 lymphocytes in patients with MD coursing a clinical episode of active depression (AD) or during no clinically active depression (NAD).Patients with MD were evaluated by psychiatrists using the International Psychiatry Interview MINI to diagnose the MD and the Hamilton Depression Rating Scale (HADRS) to define AD (N=8) and NAD (N=18) status. MD sample was 26% male and 74% female with a 25-62 year age range. Blood samples were obtained and directly stained using the following antibodies against human (CD3, CD4, CD8, CD69, CD44, PD1, LAG3, and viability dye) and analyzed by flow cytometry. This preliminary and partial analysis of the current study shows that patients with active MD have increased levels of CD69 activation marker on circulating CD4 T cells compared with patients with NAD (p