Cannabis oil one-month oral treatment given to spontaneously hypertensive rats (SHR): Could it be a promising therapeutic strategy for hypertensive cardiac hypertrophy.

PEREYRA EV; GODOY COTO J; CAVALLI F; GONZÁLEZ ARBELÁEZ LF; FANTINELLI, JC; ARANDA, O; COLMAN LERNER E; VELEZ RUEDA , JO; MOSCA, SM; ENNIS IL

Congreso; XXIV World Congress. International Society for Heart Research; 2022

Cannabis oil one-month oral treatment given to spontaneously hypertensive rats (SHR): Could it be a promising therapeutic strategy for hypertensive cardiac hypertrophy?1. Centro de Investigaciones Cardiovasculares "Horacio E. Cingolani", Facultad de Ciencias Médicas, Universidad Nacional de La Plata (UNLP) ? CONICET. Argentina. 2. Programa Ambiental de extensión universitaria (PAEU). Facultad de Ciencias Exactas UNLP. Argentina. 3. CINDECA CONICET-CIC-UNLP. Argentina.Pereyra E1; Godoy Coto J1; Cavalli F1; González Arbelaez L1; Fantinelli J. C1.; Aranda O2; Colman Lerner E3; Velez Rueda O. 1; Mosca S1; Ennis IL1. Introduction: mitochondrial alterations have been repeatedly linked to a variety of cardiovascular diseases. On the other hand, components of cannabis oil have proved cardioprotective, attenuating inflammatory and oxidative damage. Recently CBD, one of them, was found to regulate mitochondrial status. However, its effect on hypertensive cardiac hypertrophy (CH) and particularly on mitochondrial function, remains elusive. Objective: To evaluate cannabis oil treatment on CH and mitochondrial status in SHR hearts.Methods: Three-month old male SHR were randomized into treated (CO) and control (VEH). Cannabis oil or olive oil were orally administered for 1 month. We evaluated CH, myocardial histology, mitochondrial network dynamics by qPCR, mitochondrial membrane potential, myocardial superoxide dismutase (SOD), and citrate synthase activity. Data are presented as mean±SEM (n) and compared by t-Test. P