Aerobic Training Improves Hypertensive- Myocardium Mitochondria

GODOY COTO J; PEREYRA E; CAVALLI F; CALDIZ CI; YEVES AM; ENNIS IL

Congreso; Experimental Biology 2021 Meeting; 2021

Essential hypertension develops a maladaptive cardiac remodeling that alters myocardial ultrastructure and induces mitochondrial dysfunction. On the other hand, aerobic training promotes a beneficial adaptive remodeling improving the heart phenotype and function. Both signaling pathways converge in the mitochondria affecting the cell fate, as they play a critical role in heart function, homeostasis, and bioenergetics. Despite this, the intracellular adaptations triggered by aerobic training on hypertensive-myocardium mitochondria are not fully understood.Objective. To determine whether swimming training improves myocardial mitochondrial array, dynamics, and function in spontaneously hypertensive rats (SHR).Methods. 3-month-old male SHR were randomized to sedentary (Sed) or trained (Swim) groups. After an 8-week (5 days/week) swimming protocol, the hearts were destined to transmission electron microscopy (TEM) imaging, RT-PCR analysis, or mitochondrial isolation. Results are presented as mean ± SEM, except TEM data as median (IQR), and considered statistically different when p