INVESTIGADORES
ENNIS Irene Lucia
artículos
Título:
Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS).
Autor/es:
DE GIUSTI VC; CALDIZ CI; ENNIS IL; PÉREZ NG; CINGOLANI HE; AIELLO EA
Revista:
Frontiers in physiology
Editorial:
Frontiers
Referencias:
Año: 2013 vol. 4 p. 1 - 9
ISSN:
1664-042X
Resumen:
Mitochondriarepresentmajorsourcesofbasalreactiveoxygenspecies(ROS)productionofthecardiomyocyte.TheroleofROSassignalingmoleculesthatmediatedifferentintracellularpathwayshasgainedincreasinginterestamongphysiologistsinthelastyears.Inourlab,wehavebeenstudyingtheparticipationofmitochondrialROSintheintracellularpathwaystriggeredbytherenin-angiotensinII-aldosteronesystem(RAAS)inthemyocardiumduringthepastfewyears.WehavedemonstratedthatacuteactivationofcardiacRAASinducesmitochondrialATP-dependentpotassiumchannel(mitoKATP)openingwiththeconsequentenhancedproductionofmitochondrialROS.Theseoxidantmolecules,inturn,activatemembranetransporters,assodium/hydrogenexchanger(NHE-1)andsodium/bicarbonatecotransporter(NBC)viathestimulationoftheROS-sensitiveMAPKcascade.Thestimulationofsucheffectorsleadstoanincreaseincardiaccontractility.Inaddition,itisfeasibletosuggestthatasustainedenhancedproductionofmitochondrialROSinducedbychroniccardiacRAAS,andhence,chronicNHE-1andNBCstimulation,wouldalsoresultinthedevelopmentofcardiachypertrophy.
