Cofilin-1 levels and intracellular localization are associated with melanoma prognosis in a cohort of patients

BRACALENTE C; RINFLERCH A; IBAÑEZ IL; GARCIA, FM; VOLONTERI V; GALIMBERTI GN; KLAMT F; DURAN HEBE

Oncotarget

Impact Journals

Año: 2018 vol. 9 p. 24097 - 24108

1949-2553

Melanoma is an aggressive cancer with highly metastatic ability. We propose cofilin-1, a key protein in the regulation of actin dynamics and migration, as a prognostic marker. We determined cofilin-1 levels in a retrospective cohort of patients with melanomas and benign lesions of melanocytes (nevi) by immunohistochemistry. Higher cofilin-1 levels were found in malignant melanoma (MM) with Breslow Index (BI)>2 vs MM with BI2 vs MM with BI