Inhibition of benzoyl peroxide-induced tumor promotion and progression by copper(II)(3,5-diisopropyl-salicylate)2. Cancer Lett. 69(3): 167-172

DURÁN H; LANFRANCHI H; PALMIERI M; DE REY BM

CANCER LETTERS

Año: 1993 vol. 69 p. 167 - 172

0304-3835

The ability of a biomimetic superoxide dismutase agent, copper(II)(3,5-diisopropylsalicylate)2 (CuDIPS), to modulate benzoyl peroxide (BzPo)-induced tumor promotion and progression in mouse skin multistage carcinogenesis was evaluated. The results showed a significant inhibition of tumor incidence by CuDIPS pretreatment during promotion-progression. Different types of tumors were developed: papillomas, keratoacanthomas and squamous cell carcinomas. There was a significant increase in the keratoacanthoma-papilloma ratio when the period of treatment with BzPo was prolonged, which was inhibited by CuDIPS pretreatment. CuDIPS induced a significant inhibition of malignant conversion. Our results suggest that reactive oxygen species could be important in BzPo-induced promotion and progression.