Apolipoprotein B Signal peptide polymorphism distribution among south amerindian populations

DARIO A. DEMARCHI; MARCELLINO, ALBERTO; L. DE BASUALDO, MARÍA DE LOS ANGELES; COLANTONIO, SONIA; DE STEFANO, G. F.; HUTZ, MARA; SALZANO, FRANCISCO; HILL, KIM; HURTADO, MAGDALENA; CARNESE, FRANCISCO; GOICOCHEA, ALICIA; DEJEAN, CRISTINA; GUEVARA, ANGEL; CRAWFORD, MICHAEL

HUMAN BIOLOGY

Wayne State University Press

Lugar: Detroit; Año: 1999 vol. 71 p. 995 - 1000

0018-7143

We report the distribution of the APOB signal peptide polymorphism in 5 native populations ofSouth America: 2 samples of Mataco and 1 sample each of Pilaga and Toba from the ArgentinianChaco and 1 sample of Ache from the Paraguay forest. A randomly selected subsample of apreviously studied sample from the Cayapa of Ecuador (Scacchi et al. 1997) was reanalyzed toinvestigate probable differences attributable to sampling, laboratory techniques, or interobservererror. The polymorphism observed in the signal peptide region of the APOB gene among nativepopulations of South America exhibits the same range of variation found among geographiccontinental populations, confirming the high genetic heterogeneity of South Amerindians.Extremes in the allele prevalences were found among the Mataco and Ache, populations not farapart geographically. The small differences in genotype and allele frequencies between thesubsample of the Cayapa analyzed here and the original Cayapa sample and between the 2Mataco samples were not statistically significant and most likely were due to sampling error.