INV SUPERIOR JUBILADO
DAMONTE Elsa Beatriz
capítulos de libros
Título:
Junin virus
Autor/es:
DAMONTE, E.B.
Libro:
Wiley Encyclopedia of Molecular Medicine
Editorial:
Wiley
Referencias:
Año: 2002; p. 1844 - 1846
Resumen:
Junin virus (JUNV) is an arenavirus able to cause a severe, systemic disease in humans known as Argentine hemorrhagic fever (AHF), which emerged as a serious occupational hazard in certain agricultural areas of Argentina in the 1950s. The family Arenaviridae comprises a single genus, Arenavirus, which is divided into two groups, based on geographic distribution and antigenic relatedness: the Old World group and the New World group or Tacaribe complex. The Old World group includes the lymphocytic choriomeningitis virus (LCMV), the prototype species, and various African arenaviruses, whereas the Tacaribe complex comprises the South American arenaviruses such as Tacaribe virus (TACV), JUNV, and others.
The high pathogenicity in humans and its ability to easily induce chronic infections in vitro and in vivo are the most remarkable properties of JUNV. Then, research has been mainly focused on developing an effective vaccine to prevent AHF and defining the characteristics of the virus/host interaction responsible of persistent infections.
