Renal protein handling in a rat model of diabetes mellitus

SEYAHIAN, ABRIL; CACCIAGIU,LEANDRO; COSTALES-COLLAGUAZO, CRISTIAN; OCHOA FEDERICO; DÍAZ, AZUL; IARIA, ALDANA; LAGO NESTOR; DAMIANO ALICIA E; ZOTTA ELSA

Congreso; Reunión Anual de la Sociedad Argentina de Investigaciones Clínicas.; 2018

Diabetic nephropathy is the major cause of end stage renal disease worldwide. Renal protein handling is altered in diabetes mellitus and has been classically associated with glomerular alterations. Megalin and Neonatal Fc Receptor (FcRn) are two proteins located in the brush border of the proximal tubule which reabsorb filtered protein. Its possible role in the development of proteinuria has never been clearly addressed. In this work we studied Megalin and FcRn expression at two different stages of diabetic kidney disease, and its relationship with proteinuria. Diabetes was induced in male Sprague-Dawley rats after intraperitoneal injection of 65 mg/kg Streptozotocin (STZ). Studies were carried out at 15 days and 5 months post injection (n=6 for each group). 15 days post STZ injection rats presented normal glomerular filtration rate and a decrease in urinary protein excretion (p