Serum Uric Acid May Be a Differential Biomarker of Risk of Preeclampsia, Eclampsia and Gestational Hypertension Development.

COROMINAS ANA; BALCONI SILVIA; DIETRICH VALERIA; MASKIN BERNARDO; DAMIANO ALICIA E

Santiago

Congreso; International Federation of placenta Associations Meeting; 2010

International Federation of placenta Associations

Preeclampsia is a hypertensive disorder unique to human pregnancy which etiology is still unknown. It is responsible for approximately 12% of the world maternal deaths. Clinically, it is diagnosed primarily by the onset of hypertension and proteinuria in the later half of gestation. Eclampsia is the final and most severe phase of preeclampsia and can cause coma, seizures and even death of the mother and baby. Gestational hypertension is defined as the development of new arterial hypertension in a pregnant woman after 20 weeks of gestation without proteinuria.Up to now, predicting which women is at risk of developing preeclampsia -eclampsia is difficult. Here, we evaluate uric acid concentrations during the course of pregnancy to differentiate women who are at risk of preeclampsia-eclampsia development from women who have gestational hypertension. We conducted a case-control study of 138 women (49 with uncomplicated pregnancies, 62 with preeclampsia, 17 with eclampsia and 10 with gestational hypertension).Serum uric acid, proteinuria, urea and creatinine were measured both before and after the 20th week of gestation. We compared all groups and found no significant differences in serum uric acid levels before the 20th week of gestation. However, after the 20th weeks of gestation serum uric acid levels from preeclamptic-eclamptic women were higher than levels from women with gestational hypertension (P