RELATIONSHIP OF URICEMIA LEVELS IN GESTATIONAL HYPERTENSIVE DISEASES AND THE TYPE OF DELIVERY

COROMINAS ANA; BALCONI SILVIA; FERREIROS, ALBERTO; CASALE, ROBERTO; DAMIANO, ALICIA E.

Bogotá (Virtual)

Simposio; IX Simposio de la Sociedad Latinoamericana de Interacción Materno-Fetal y Placenta; 2022

Objectives: The onset of maternal symptoms in gestational hypertensive diseases takes place with an endothelial inflammation syndrome, characterized by hypertension and proteinuria, and high uricemia levels. This increase in uricemia levels precedes the clinical manifestations and can be considered a risk marker for these diseases. However, the association between uricemia levels in gestational hypertensive diseases and the type of delivery is unknown.We aimed to describe the dynamic of uricemia in hypertensive gestational diseases and its correlation with the type of delivery.Methods: A retrospective descriptive-quantitative study was carried out in all women with gestational hypertensive diseases and normal gestations who attended their pregnancy at the Hospital Posadas during 2018. Type of pregnancy, birth weight, gestational age, type of delivery, days of hospitalization of the newborn and the mother, and uricemia before and after the 20th week of gestation were analyzed.Results: 4129 single deliveries were studied. Among them, 131 developed preeclampsia (PE), 267 gestational hypertension (GH), and 3731 were normotensive pregnancies.Uricemia levels before the 20th week of gestation were similar in all groups studied. In preeclamptic women who required cesarean section, uricemia levels were higher (6.05 ± 1.56 mg/dl and 5.06 ± 1.51 mg/dl, early and late-onset PE respectively) than in those preeclamptic women who had a spontaneous vaginal delivery (4.84 ± 1.59 mg/dl, late-onset), values with statistic significance when compared with GH and normotensive pregnancies.In all groups, higher uricemia levels were also associated with an increase in the number of days of maternal and newborn hospitalization.Conclusion: The increase in uric acid levels during pregnancy is associated with the severity of the presentation of gestational hypertensive pathology. In addition, it reflects a level of endothelial inflammation generated during the cesarean section that is not observed in spontaneous vaginal deliveries.