Reduced Expression Of Na(+)/H(+) Exchanger Isoform 3 (Nhe-3) In Preeclamptic Placentas

DIETRICH VALERIA; SZPILBARG NATALIA; DAMIANO, ALICIA E

PLACENTA

W B SAUNDERS CO LTD

Año: 2013 vol. 34 p. 828 - 830

0143-4004

Although the etiology of preeclampsia is unknown, accumulated evidence suggests that the expression of a variety of syncytiotrophoblast transporters is reduced or abnormal. Here, we have examined the expression of NHE-3 in preeclamptic placentas. We found that NHE-3 expression significantly decreased and that its labeling in the apical membrane and the cytosol of syncytiotrophoblast was reduced. Even though the inductor mechanisms of NHE-3 decrease are not clear yet, we speculated that alterations in TNF-alpha and aldosterone levels observed in preeclampsia might be downregulating NHE-3 expression. Further studies are needed to determine the role of NHE-3 in the pathogenesis of preeclampsia.