Synthesis of antifungal compounds for soya cultures preservation.

BARRADAS JOSÉ S.; ERREA MARÍA I.; D'ACCORSO NORMA B.

Palermo - Italia

Congreso; 20th International Congress of Heterocyclic Chemistry; 2005

International Heterocyclic Chemistry Society

Synthesis of antifungal compounds for soya cultures preservation Barradas, Sebastián; Errea, María Inés y D´ Accorso Norma Beatriz Dpto. de Química Orgánica, CIHIDECAR-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires. Argentina. norma@qo.fcen.uba.ar Soya is a primary source of edible proteins and an important component of nutritionally balanced meals. Fungal infections, which could occur even during cultivation o post-harved, represent an important damage for the economy of many countries. Serious limitations of the existing drugs, as well as resistance against them have led to an emergent need to develop new chemical entities as antifungal agents. Looking for new fungicides, we report the synthesis of 1,4-dihydro-5-(4-halophenyl)-4-substituted 1,2,4-triazoline-3-thiol/thiones. The synthetic pathway, exemplified with glucose is shown in the scheme1-3. The antifungal activity of the new compounds will be tested.                                                     1) Jiménez Blanco, J. L.; García Fernández, J. M.; Gadelle, A.; Defaye, J. Carbohydr. Res. 1997, 303, 367-372.                                                     1) Jiménez Blanco, J. L.; García Fernández, J. M.; Gadelle, A.; Defaye, J. Carbohydr. Res. 1997, 303, 367-372. (2) García-Moreno, M. I.; Díaz-Pérez, P.; Benito, J. M.; Mellet, C. O.; Defaye, J.; García Fernández, J. M. Carbohydr. Res. 2002, 337, 2329-2334. (3) Duran, A.; Dogan, H. N.; Rollas, S. Il Fármaco 2002, 57, 559-564.