In vivo antitumoral activity and acute toxicity study of Larrea divaricata Cav.

C ANESINI; J BOCCIO; G CREMASCHI; AM GENARO; M ZUBILLAGA; L STERIN BORDA; E BORDA

PHYTOTHERAPY RESEARCH

Wiley Interscience

Lugar: England; Año: 1997 vol. 11 p. 521 - 523

0951-418X

In the present work we analuysed the effect of the extract of Larrea divaricata Cav on a mammary carcinoma chemically induced by N-nitroso-N-methylurea in female rats. The extract was administered in a dose of 25 mg/Kg, subcutaneously, beginning 20 days after tumor appearence. Of a total of 75 tumors treated with the extract a regression of 10 tumors (13%) was observed, a stabilization of 60 tumors (80%) and an increment of 5 tumors (6%).  None of the 80 control tumors decreased (0%) and only 12 tumors remain static (15%). The LD50 in females was lower than in male mice. Data indicate that the aqueous extract of Larrea divaricata Cav. could be considered to stop tumor growth as the extract bloked progression of the tumors.