Down-regulation of ß adrenergic receptors induced by mitogen activation of intracellular signaling events in lymphocytes.

C CAZAUX; L STERIN-BORDA; G GORELIK; GA CREMASCHI

FEBS LETTERS

Elsevier Science B.V.

Lugar: Netherlands; Año: 1995 vol. 364 p. 120 - 124

0014-5793

The expression of beta-adrenergic receptors on murine lymphocytes stimulated with concanavalin A was studied. A decrease in beta-adrenoceptor number on T lymphocytes and a diminished response to specific agonist stimulation at the peak of proliferation was found. The blockade of cell proliferation by tyrosine kinases or protein kinase C inhibitors reversed the decrease in beta-adrenoceptor number. PMA plus ionophore or interleukin-2 but not PMA alone were able to induce beta-adrenoceptor down-regulation accompanying cellular proliferation. These results showed that the intracellular signals triggered during lymphocyte activation are involved in beta-adrenoceptor down-regulation and it would represent the loss of a mechanism that exerts negative neuroimmune control of cellular proliferation.