INVESTIGADORES
CREMASCHI Graciela Alicia
artículos
Título:
Tilia cordata Mill. Extracts and scopoletin (isolated compound): differential cell growth effects on lymphocytes.
Autor/es:
M.L. BARREIRO ARCOS; G. CREMASCHI; S. WERNER; J. COUSSIO; G. FERRARO; C. ANESINI
Revista:
PHYTOTHERAPY RESEARCH
Editorial:
John Wiley & Sons, Ltd.
Referencias:
Lugar: USA; Año: 2006 vol. 20 p. 34 - 40
ISSN:
0951-418X
Resumen:
Aqueous extracts or infusions obtained from the flowers of Tilia
species are widely used for the treatment of anxiety in folk medicine.
In this work, the antiproliferative action of aqueous, dichloromethane
and ethanol extracts obtained from Tilia cordata Mill. flowers on
tumoral (BW 5147 lymphoma) and normal lymphocytes is described. Both
extracts showed a selective action on tumoral cells, inducing
apoptosis. In the case of normal T cells these extracts suppressed
mitogen-induced proliferation without affecting viability, suggesting a
suppressive but not cytotoxic effect. These effects were clearly
concentration dependent. A coumarin (scopoletin), the main component in
the dichloromethane extract presented antiproliferative action on BW
5147 cells, suggesting that it may be at least partly responsible for
the activity displayed by this extract.