LPS induces ciclooxygenase-2 expression in Y1 adrenal cells: involvement of PI3K/Akt and p38 MAPK signaling pathways

MARÍA E MERCAU; ELIAN F GIORDANINO; FRANCISCO ASTORT; NICOLÁS BENFATTO; JUAN M OLEJARCZYK; OMAR A. COSO; CORA B. CYMERYNG

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Congreso; SISTAM 2012 - The Second South American Spring Symposium in Signal Transduction and Molecular Medicine? (SISTAM2012); 2012

42.- LPS induces ciclooxygenase-2 expression in Y1 adrenal cells: involvement of PI3K/Akt and p38 MAPK signaling pathways María E Mercau; Elian F Giordanino; Francisco Astort; Nicolás Benfatto; Juan M Olejarczyk; Omar A. Coso and Cora B Cymeryng Department of Human Biochemistry, School of Medicine, University of Buenos Aires, CEFYBO-CONICET, Buenos Aires, Argentina Previous studies from our laboratory have shown that LPS treatment stimulates adrenal steroid synthesis in Y1 cells by a mechanism involving NFkB-dependent COX-2 induction. Present experiments were designed to analyze the involvement of p38 MAPK and PI3K/AkT signaling cascades in this effect. An increase in p38 MAPK and Akt phosphorylation was observed 30 minutes after the initiation of LPS treatment (p