Phenotypic and functional characterization of peripheral T cell populations from COVID-19 patients hospitalized in Hospital Privado Universitario Córdoba- Argentina

ONOFRIO L*, DUTTO J*, BOSSIO S*, BAIGORRI E*, BRUGO MB*, ALMADA L**, MARÍN C**, RUIZ MORENO F**, VOLPINI X**, ALMEIDA M, OLIVERA C, PONCE N, QUIROZ JM, SILVERA RUIZ S, BOFELLI L, ACOSTA RODRÍGUEZ E, AMEZCUA VESELY C, ARROYO D, CERBÁN F; CERVI L, FOZZATTI L, ICELY P, IRIBARREN P, MALETTO B, MORÓN G, RODRÍGUEZ GALÁN C, STEMPIN C,; BERTONE M#, ABIEGA A#, ESCUDERO D#, KAHN A#, CAEIRO JP#,; MACCIONI M, MOTRÁN M, CHIAPELLO L, MONTES C, GRUPPI A, SOTOMAYOR C. GRUPO IMMUNOCOVIDCBA

Congreso; . LXIX Reunión Annual de la Sociedad Argentina de Inmunología (SAI); 2021

SARS-CoV-2 infection results in asymptomatic, mild or severedisease. T cells could contribute to these different outcomes, butit remains unclear whether T cell response is dysfunctional or excessive.Here, we evaluated the phenotypic and functional featuresof circulating T cells from a cohort of 40 COVID-19 patients (Cpts)with moderate (MOD) and severe (SEV) clinical disease (aged 21-80 years) and 14 aged matched healthy controls (HC) by FACS. AllCpts exhibited a reduced frequency of CD3+T and Tregs cells compareto HC (p< 0.05). When exhaustion was evaluated, SEV Cptsshowed higher % of PD-1+ and CD39+ in T conv cells (p