Dynamics of soluble immune mediators in COVID-19 patients from an Argentinean cohort with moderate and severe symptoms

L ALMADA*, SC ANGIOLINI*, N DHO N*, J DUTTO J*, Y GAZZONI Y*, C MANZONE *, C MARÍN *, NE PONCE, P IRIBARREN, F CERBÁN, G MORÓN, C AMEZCUA VESELY, Y ANA,; L CERVI, L CHIAPELLO, L FOZZATTI L, P ICELY, M MACCIONI, C MENA, C MONTES, C MOTRÁN , C RODRÍGUEZ GALÁN, C STEMPIN, ME VIANO; M BERTONE#, C ABIEGA#, D ESCUDERO#, A KAHN#, JP CAEIRO#, ; MACCIONI M, MOTRÁN M, CHIAPELLO L, MONTES C, GRUPPI A, SOTOMAYOR C. GRUPO IMMUNOCOVIDCBA

Congreso; . LXIX Reunión Annual de la Sociedad Argentina de Inmunología (SAI); 2021

The cytokine storm, a form of systemic inflammatory response syndrome,is one of the most dreadful complications that can occurduring COVID-19. In this work, we aimed at studying the occurrenceof a cytokine storm in a cohort of COVID-19 patients (Cpts) from Córdoba(Argentine). During first wave, we collected sera from individualswith RT-PCR+ for SARS-CoV2 hospitalized in Hospital Privadowith moderate (MOD) and severe (SEV) disease (n=62, aged 21-80years) as well as healthy controls (HC n=24, age matched), to determinethe concentrations of IL-1b, IL-6, IL-8, IL-10, IL-12, IL-28A/B,IL-29, TNF, IP-10, IFNa2, IFNb, IFNg and GM-CSF by LEGENDplexTM.Males represented 74% of MOD and 67% of SEV Cpts. Hypertension(HT, 48%), obesity (31%), dyslipidemia (DL, 24%), anddiabetes (24%) were the most frequent comorbidities. All cytokines,except IL-28A/B, were significantly increased in total Cpts in comparisonwith HC (p