Transposons and integrons in colistin resistant clones with epidemic or sporadic behavior

ARDUINO SM, QUIROGA MP, RAMÍREZ MS, MERKIER AK, ERRECALDE L, DI MARTINO A, SMAYEVSKY J, KAUFMAN S, CENTRÓN D.

JOURNAL OF MEDICAL MICROBIOLOGY

SOC GENERAL MICROBIOLOGY

Lugar: London; Año: 2012 vol. 61 p. 1417 - 1420

0022-2615

Multiple transposons, integrons and carbapenemases were found in Klebsiella pneumoniae colistin-resistant isolates as well as a genomic resistance island of the AbaR type in Acinetobacter baumannii colistin-resistant isolates from different hospitals from Buenos Aires City. PFGE analysis showed a polyclonal dissemination of antimicrobial resistance mechanisms among K. pneumoniae isolates, while in A. baumannii isolates the epidemic clone 1 from South America was found. Resistance determinants associated with horizontal gene transfer are contributing to the evolution to pandrug resistance in both epidemic and sporadic clones.