Acetylcholine polarizes dendritic cells toward a Th2- promoting profile

SOLEDAD GORI 1; MÓNICA VERMEULEN; FEDERICO REMES-LENICOV; CAROLINA JANCIC; WALTER SCORDO; ANA CEBALLOS; NADIA TOWSTYKA; YESICA BESTACH; CAROLINA BELLI; FLORENCIA SABBIONE; JORGE GEFFNER; GABRIELA SALAMONE

ALLERGY

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2016

0105-4538

A growing body of research shows a reciprocal regulation between the neural and immunesystems. Acetylcholine (ACh) is the most important parasympathetic neurotransmitter andincreasing evidence indicates that it is able to modulate the immune response.Interestingly, in recent years it has become clear that immune cells express a nonneuronalcholinergic system, which is stimulated in the course of inflammatory processes. We havepreviously shown that dendritic cells (DC) express muscarinic receptors, as well as theenzymes responsible for the synthesis and degradation of ACh. Here, we analyzedwhether ACh could also modulate the functional profile of DC.