Oxitocin and prostaglandins F2á and E2 do not enhance HIV-1 antigen production in vitro

CEBALLOS A, . , ; ROBERTO D RABINOVICH, ; SILVIA MARQUINA, ; PABLO N. FERNÁNDEZ LARROSA; LILIANA MARTINEZ PERALTA

ARCHIVES OF VIROLOGY

SPRINGER WIEN

Año: 2003 vol. 148 p. 531 - 535

0304-8608

1: Arch Virol. 2003 Mar;148(3):531-5.Oxytocin and prostaglandins F2alpha and E2 do not enhance HIV antigen production in vitro.Ceballos A, Rabinovich RD, Marquina S, Fernández Larrosa PN, Martinez Peralta L.National Reference Center for AIDS, Department of Microbiology, University ofBuenos Aires, School of Medicine, Buenos Aires, Argentina. aceballo@fmed.uba.arOxytocin and prostaglandins (PGs) are hormones involved in labor and are usedclinically for its induction. In this study the effect of oxytocin, PGF(2alpha), and PGE(2) on Humour immunodeficiency virus-1 production in acutely andpersistently infected cells was measured. No significant effect on p24 antigenproduction was found with oxytocin or PGs, except for a transient decrease inpersistently infected cells treated with 1 micro M PGF(2alpha). These resultsshowed that oxytocin and PGs could be used clinically for labor induction withoutany direct enhancement in viral production. Besides, the results with PGF(2alpha)at the highest concentration studied may indicate a pharmacological effect.