Understanding the interactions between metabolites isolated from Achyrocline satureioides in relation to its antibacterial activity

JORAY M.B.; PALACIOS S. M.; CARPINELLA M. C.

PHYTOMEDICINE

ELSEVIER GMBH

Año: 2013 vol. 20 p. 258 - 261

0944-7113

Part of our ongoing research on the antibacterial activity of Achyrocline satureioides,this study seeks to better understand the interactions between the metabolites isolated from this plant. For this purpose, the combined effect of 23-methyl-6-O-desmethylauricepyrone (1), quercetin (2) and 3-O-methylquercetin (3), obtained through bioguided fractionation from A. satureioides ethanol extract, was evaluated against Staphylococcus aureus and Escherichia coli. In first place, the antibacterial effect of the combination of flavonols 2 and 3 was assessed, as these showed individual effectiveness lower than or equal to that of the fraction from which they were obtained. When the flavonols were applied together at concentrations below their minimum inhibitory concentration (MIC) values, a synergistic effect (FICI