CAMPERI Silvia Andrea
Temporins. An approach of potential pharmaceutical candidates
S. M. ROMERO; A. CARDILLO; M. C. MARTÍNEZ-CERON; S. A. CAMPERI; S. L. GIUDICESSI
Mary Ann Liebert, Inc.
Objective: Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are small and mostly polycationic molecules that form part of the innate immune response. There are currently more than 3000 experimentally reported AMPs. Particularly, in frogs, a new family, the temporins, have been discovered as potential AMPs. The aim of this work is to review the latest publications about this class of peptides, discuss their properties and make an update of the last studies and new discoveries in the field.Evidence acquisition: For the acquisition of the references in this research, we used Pub Med, NCBI and Google. The key words for the research in the bet were temporins, antimicrobial peptides, antifungal, natural drugs, nanotechnology. Results: More than 130 members of the temporin family have been identified in this family. The most studied temporins are temporin A (TA), temporin B (TB) and temporin L (TL). These peptides showed antimicrobial activity against Gram-negative, Gram-positive bacteria and fungi. Since the discovery of temporins in 1996, several groups of research isolated different peptides from various species of frogs that were include as members of this family. Although antimicrobial activity of many temporins has not been analyzed yet, most of them showed antimicrobial and antifungal activities. Combination of nanotechnology and AMPs as temporins in different antimicrobial treatments could be a promising alternative for resistance pathogens. Conclusion: These studies demonstrate that, even with the advancement in scientific research on the composition and antimicrobial activity of temporins, further studies are necessary to wholly understand their components and mechanisms of action.