INVESTIGADORES
CABRERA Gabriela Myriam
artículos
Título:
. Sterol analogues with diamide side chains interfere with the intracellular localization of viral glycoproteins
Autor/es:
MARÍA E DÁVOLA; FERNANDO ALONSO; GABRIELA M. CABRERA; JAVIER A. RAMIREZ; ANDREA BARQUERO
Revista:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 427 p. 107 - 112
ISSN:
0006-291X
Resumen:
The need to develop novel antiviral agents encouraged us to assess the antiviral activity of synthetic sterol
analogues with a diamide side chains. Cytotoxicity and antiviral activity of a family of azasterol previously
synthesized was evaluated against herpes simplex virus 1 (HSV-1) (KOS and B2006) and vesicular
stomatitis virus (VSV). This family of compounds was extended by the synthesis of novel analogs using an
Ugi multicomponent reaction and their ability to inhibit viral multiplication was also evaluated. The
results show that some of the compounds tested exert an antiviral activity. Besides, the effect of the azasterols
on the intracellular localization of viral glycoproteins was examined. Strikingly, alteration on the
glycoprotein D (gD) of HSV-1 fluorescence pattern was observed with both the antiherpetic compounds
and the inactive azasterols.