An Antifungal Tetrapeptide from the Culture of Penicillium canescens

BERTINETTI BRENDA; PENA, NORA; CABRERA GABRIELA M.

Chemistry and Biodiversity

WILEY-V C H VERLAG GMBH

Año: 2009 p. 1178 - 1184

1612-1872

A not previously described tetrapeptide d-Phe-l-Val-d-Val-l-Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium canescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapeptide, which possess antifungal activity comparable with that of the commercial product benomyl against the soybean phytopathogen Fusarium virguliforme, was determined by spectroscopic (2D NMR, MS and MS/MS) and chemical methods and the sequence was confirmed by comparison with authentic synthetic isomeric peptides.