Atrial natriuretic peptide and angiotensin II interaction on noradrenaline uptake in the central nervous system.

BELISARIO E. FERNANDEZ; ANTONIO DOMINGUEZ; MARCELO S. VATTA; MARIA ALEJANDRA MENDEZ; LILIANA G. BIANCIOTTI; ALEJANDRO MARTINEZ SEEBER

ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE

Heymans Institute of Pharmacology

Año: 1990 vol. 307 p. 11 - 17

0301-4533

The effect of different concentrations of atrial natriuretic peptide and angiotensin II on [3H] noradrenaline uptake in hypothalamus and medulla oblongata slies incubated in vitro was determined. Atrial natriuretic peptide in a dose of 100nM increased [3H] noradrenaline uptake in both regions while 1uM angiotensin II had the opposite effect. The innefective concentration of 1uM atrial natriuretic peptide reversed the action of 1uM angiotensin II on [3H] noradrenaline uptake, whereas ineffective concentrations of angiotensin II failed to modify atrial natriuretic peptide effects. These results are compatible with the existence of an atrial natriuretic peptide-angiotenin II interaction in the central nervous system and with the hypothesis that some of the hypotensive effects of atrial natriureticc peptide could occur through the modulation of an andiotensin-nordrenergic mechanism in the central nervous system.