Photosensitizer-dendrimer systems in anticancer treatments: From photophysics to PDT applications

. ERNESTO M. ARBELOA; M. PAULA MILITELLO; SONIA G. BERTOLOTTI; CARLOS M. PREVITALI

Dendrimers-based nanotherapeitics

Elsevier

Año: 2021; p. 311 - 326

Advances in the application of nanotechnology in medicine have given rise to multifunctional smartnanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. Dendrimers having properties resembling biomolecules, withwell-defined 3D nanopolymeric architectures, are emerging as a highly attractive class of drug and gene delivery vector. The presence of numerous peripheral functional groups on hyperbranched dendrimers affords efficient conjugation of targeting ligands and biomarkers that can recognize and bind to receptors overexpressed on cancer cells for tumor cell-specific delivery.This book compiles the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in exploring dendrimers in the field of drug delivery. It will cover all the information starting from history to most recent research till date. Starting chapter will cover detailed information about basic properties about dendrimers, that is, properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapter will be discussing the most recent and advancement in the field of dendrimer, that is, dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances intargeted dendrimers for cancer therapy, and future considerations of dendrimers. It will be helpful for the scientists/researchers involved in health sector specifically those working for developing novel cancer therapy using dendrimer-based delivery systems. It will also help fresh PhD aspirantsin providing them with a comprehensive overview of the potential role of dendrimer in treatment of various diseases. Furthermore, the book will be useful for graduates, postgraduate, clinical researchers, and anyone working in development of dendrimer-related research by various routes such as ocular, oral, vaginal, nose to the brain, etc.We thank all the authors for their valuable and timely contributions. We believe that the book, with its comprehensive coverage of fundamental and applied aspects of the dendrimer, will prove immensely useful to its readers and stimulate further interest