Anticonvulsant effect of Sodium cyclamate and propylparaben on PTZ-induced seizures in zebrafish.

PISERA-FUSTER A, OTERO S, TALEVI A, BRUNO-BLANCH L & BERNABEU R

SYNAPSE

WILEY-LISS, DIV JOHN WILEY & SONS INC

Año: 2017

0887-4476

Screeningfor novel anticonvulsant drugs requires appropriate animal seizure models.Zebrafish provide small, accessible and cost-efficient preclinical modelsapplicable to high-throughput small molecule screening. Based in previous results inrodents, we have here examined the effects of artificial sweetener sodiumcyclamate and antimicrobial agent sodium propylparaben on a model of PTZ-inducedseizures in zebrafish. Sodium cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency tospasms and the latency to seizure, while propylparaben increased the latency tospasms. The results show the potential of zebrafish to detect novelanticonvulsant compounds while they also demonstrate the ability of twocommonly ingested chemical compounds to modify the seizure threshold when wereadministrated at low concentration.