INVESTIGADORES
BERNABEU Ramon Oscar
artículos
Título:
Reversible changes in hippocampal 3[H]-AMPA binding following inhibitory avoidance training in the rat.
Autor/es:
CAMMAROTA, M., BERNABEU, R., IZQUIERDO, I. & MEDINA, J.
Revista:
NEUROBIOLOGY OF LEARNING AND MEMORY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 1996 vol. 66 p. 85 - 88
ISSN:
1074-7427
Resumen:
We have recently shown that inhibitory avoidance training produces a
rapid, selective, and learning-specific increase in the number of
3H-AMPA glutamate receptors in several subfields of the dorsal
hippocampal formation in the rat. In the present study we investigated
the posttraining temporal course of this enhancement by quantitative
autoradiography of 3H-AMPA binding. Confirming previous results, rats
submitted to a step-down inhibitory avoidance paradigm showed a marked
increase (50-90%) in hippocampal 3H-AMPA binding that peaked 2 h
posttraining. In CA3 and dentate gyrus this increase persisted for at
least 48 h following training. In contrast, 24 h after training the
binding of 3H-AMPA in the CA1 subfield did not differ significantly from
naive control values. In all hippocampal regions studied, the binding
of 3H-AMPA at 168 h posttraining reached control values. No changes were
observed in the shocked or free exploration groups in comparison with
naive controls. The results suggest that hippocampal AMPA receptors
undergo rapid and reversible changes after inhibitory avoidance learning
and give further support to the hypothesis that changes in hippocampal
AMPA receptors participate in the synaptic plasticity mediating certain
forms of learning and memory.